Cell Senescence Entries for EIF4EBP1

Cell Types
Lung fibroblast
Cell Lines
MRC-5
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Petroulakis et al. (2009) p53-dependent translational control of senescence and transformation via 4E-BPs. Cancer Cell 16(5)439-46 (PubMed)

EIF4EBP1 Gene Information

HGNC symbol
EIF4EBP1 
Aliases
4E-BP1; PHAS-I 
Common name
eukaryotic translation initiation factor 4E binding protein 1 
Entrez Id
1978
Description
This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008].

EIF4EBP1 Ontologies

Gene Ontology
Process: GO:6417; regulation of translation
GO:17148; negative regulation of translation
GO:45947; negative regulation of translational initiation
GO:82; G1/S transition of mitotic cell cycle
GO:45931; positive regulation of mitotic cell cycle
GO:31929; TOR signaling
Cellular component: GO:5829; cytosol
GO:5737; cytoplasm
Function: GO:8190; eukaryotic initiation factor 4E binding
GO:5515; protein binding
GO:30371; translation repressor activity
Hide GO terms

Homologs of EIF4EBP1 in Model Organisms

Mus musculus
Eif4ebp1
Rattus norvegicus
Eif4ebp1

In other databases

LongevityMap
CellAge gene expression

External links

OMIM
602223
Ensembl
ENSG00000187840
Entrez Gene
1978
UniGene
411641
1000 Genomes
1000 Genomes
HPRD
GenAtlas
EIF4EBP1
GeneCards
EIF4EBP1