Cell Senescence Entries for ELOA

Cell Types
Mammary fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Avelar et al. (2021) A multidimensional systems biology analysis of cellular senescence in aging and disease. Genome Biol 21(1)91 (PubMed)

ELOA Gene Information

HGNC symbol
ELOA 
Aliases
SIII; TCEB3; TCEB3A 
Common name
elongin A 
Entrez Id
6924
Description
This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008].

ELOA Ontologies

Gene Ontology
Process: GO:6368; transcription elongation from RNA polymerase II promoter
GO:6367; transcription initiation from RNA polymerase II promoter
GO:6357; regulation of transcription by RNA polymerase II
GO:6414; translational elongation
Cellular component: GO:5634; nucleus
GO:5615; extracellular space
GO:70449; elongin complex
GO:5654; nucleoplasm
GO:90734; site of DNA damage
GO:110165; cellular anatomical entity
Function: GO:5515; protein binding
GO:3746; translation elongation factor activity
Hide GO terms

Homologs of ELOA in Model Organisms

Mus musculus
Tceb3
Rattus norvegicus
Tceb3

External links

OMIM
600786
Ensembl
ENSG00000011007
Entrez Gene
6924
UniGene
15535
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ELOA
GeneCards
ELOA