Cell Senescence Entries for EP300

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced, Replicative
Senescence Effect
Induces
Primary Reference
Sen et al. (2019) Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence. Mol Cell 73(4)684-698.e8 (PubMed)

EP300 Gene Information

HGNC symbol
EP300 
Aliases
KAT3B; p300 
Common name
E1A binding protein p300 
Entrez Id
2033
Description
This gene encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. It functions as histone acetyltransferase that regulates transcription via chromatin remodeling and is important in the processes of cell proliferation and differentiation. It mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. This gene has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. Defects in this gene are a cause of Rubinstein-Taybi syndrome and may also play a role in epithelial cancer. [provided by RefSeq, Jul 2008].

EP300 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:6355; regulation of transcription, DNA-templated
GO:6915; apoptotic process
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:7623; circadian rhythm
GO:48511; rhythmic process
GO:16573; histone acetylation
GO:6473; protein acetylation
GO:45444; fat cell differentiation
And 57 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5694; chromosome
GO:123; histone acetyltransferase complex
GO:5667; transcription regulator complex
GO:32993; protein-DNA complex
GO:32991; protein-containing complex
Function: GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:3713; transcription coactivator activity
GO:3677; DNA binding
GO:3712; transcription coregulator activity
GO:16746; acyltransferase activity
GO:5515; protein binding
GO:4402; histone acetyltransferase activity
GO:3684; damaged DNA binding
GO:140297; DNA-binding transcription factor binding
And 28 more GO terms
Show all GO terms

Homologs of EP300 in Model Organisms

Danio rerio
ep300a
Mus musculus
Ep300

In other databases

GenAge human genes
  • This gene is present as EP300

External links

OMIM
602700
Ensembl
ENSG00000100393
Entrez Gene
2033
UniGene
655211
1000 Genomes
1000 Genomes
HPRD
GenAtlas
EP300
GeneCards
EP300