Cell Senescence Entries for ETS1

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
HS68, TIG-3
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Ohtani et al. (2001) Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence. Nature 409(6823)1067-70 (PubMed)

ETS1 Gene Information

HGNC symbol
ETS1 
Aliases
ETS-1; EWSR2; FLJ10768 
Common name
ETS proto-oncogene 1, transcription factor 
Entrez Id
2113
Description
This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011].

ETS1 Ontologies

Gene Ontology
Process: GO:10628; positive regulation of gene expression
GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:2376; immune system process
GO:30154; cell differentiation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6955; immune response
GO:50729; positive regulation of inflammatory response
GO:45766; positive regulation of angiogenesis
GO:8285; negative regulation of cell population proliferation
And 14 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:785; chromatin
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:1222; transcription corepressor binding
GO:976; transcription cis-regulatory region binding
And 2 more GO terms
Show all GO terms

Homologs of ETS1 in Model Organisms

Mus musculus
Ets1
Rattus norvegicus
Ets1

In other databases

CellAge gene expression
  • This gene is present as ETS1

External links

OMIM
164720
Ensembl
ENSG00000134954
Entrez Gene
2113
UniGene
369438
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ETS1
GeneCards
ETS1