Cell Senescence Entries for ETV6

Cell Types
Foreskin fibroblast
Cell Lines
NHDF
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Latorre et al. (2019) FOXO1 and ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence. FASEB J 33(1)1086-1097 (PubMed)

ETV6 Gene Information

HGNC symbol
ETV6 
Aliases
TEL 
Common name
ETS variant transcription factor 6 
Entrez Id
2120
Description
This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [provided by RefSeq, Sep 2008].

ETV6 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:7296; vitellogenesis
GO:22008; neurogenesis
GO:30154; cell differentiation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:97152; mesenchymal cell apoptotic process
GO:122; negative regulation of transcription by RNA polymerase II
GO:71425; hematopoietic stem cell proliferation
Cellular component: GO:5634; nucleus
GO:5730; nucleolus
GO:5829; cytosol
GO:5886; plasma membrane
GO:785; chromatin
GO:16020; membrane
GO:16021; integral component of membrane
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:19904; protein domain specific binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
And 1 more GO terms
Show all GO terms

Homologs of ETV6 in Model Organisms

Mus musculus
Etv6
Rattus norvegicus
Etv6

External links

OMIM
600618
Ensembl
ENSG00000139083
Entrez Gene
2120
UniGene
504765
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ETV6
GeneCards
ETV6