Cell Senescence Entries for FANCD2

Cell Types
Dermal fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Hovest et al. (2012) Differential roles for Chk1 and FANCD2 in ATR-mediated signalling for psoralen photoactivation-induced senescence. Exp Dermatol 20(11)883-9 (PubMed)

FANCD2 Gene Information

HGNC symbol
FANCD2 
Aliases
FA-D2; FACD; FAD; FANCD 
Common name
FA complementation group D2 
Entrez Id
2177
Description
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].

FANCD2 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:31573; mitotic intra-S DNA damage checkpoint signaling
GO:36297; interstrand cross-link repair
GO:7129; homologous chromosome pairing at meiosis
GO:10332; response to gamma radiation
GO:1990918; double-strand break repair involved in meiotic recombination
GO:7276; gamete generation
GO:34599; cellular response to oxidative stress
GO:45589; regulation of regulatory T cell differentiation
And 6 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5829; cytosol
GO:16604; nuclear body
GO:785; chromatin
GO:793; condensed chromosome
GO:1990391; DNA repair complex
Function: GO:5515; protein binding
GO:70182; DNA polymerase binding
Show all GO terms

Homologs of FANCD2 in Model Organisms

Caenorhabditis elegans
fcd-2
Danio rerio
fancd2
Drosophila melanogaster
Fancd2
Mus musculus
Fancd2
Rattus norvegicus
Fancd2

In other databases

LongevityMap
  • This gene is present as FANCD2
CellAge gene expression
  • This gene is present as FANCD2

External links

OMIM
613984
Ensembl
ENSG00000144554
Entrez Gene
2177
UniGene
208388
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FANCD2
GeneCards
FANCD2