Cell Senescence Entries for FERMT2

Cell Types
Breast cancer
Cell Lines
BT549
Cancer Cell?
Yes
Method
Knockout
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Sossey-Alaoui et al. (2020) The Kindlin2-p53-SerpinB2 signaling axis is required for cellular senescence in breast cancer. Cell Death Dis 10(8)539 (PubMed)

FERMT2 Gene Information

HGNC symbol
FERMT2 
Aliases
KIND2; mig-2; PLEKHC1; UNC112B 
Common name
FERM domain containing kindlin 2 
Entrez Id
10979
Description

FERMT2 Ontologies

Gene Ontology
Process: GO:7155; cell adhesion
GO:16055; Wnt signaling pathway
GO:7229; integrin-mediated signaling pathway
GO:72657; protein localization to membrane
GO:8360; regulation of cell shape
GO:7160; cell-matrix adhesion
GO:48041; focal adhesion assembly
GO:7179; transforming growth factor beta receptor signaling pathway
GO:43116; negative regulation of vascular permeability
GO:22604; regulation of cell morphogenesis
GO:30335; positive regulation of cell migration
GO:33622; integrin activation
GO:1900182; positive regulation of protein localization to nucleus
GO:51897; positive regulation of protein kinase B signaling
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:34446; substrate adhesion-dependent cell spreading
GO:45599; negative regulation of fat cell differentiation
GO:45669; positive regulation of osteoblast differentiation
GO:43547; positive regulation of GTPase activity
GO:51894; positive regulation of focal adhesion assembly
GO:10718; positive regulation of epithelial to mesenchymal transition
GO:1900026; positive regulation of substrate adhesion-dependent cell spreading
GO:60548; negative regulation of cell death
GO:51496; positive regulation of stress fiber assembly
GO:33625; positive regulation of integrin activation
GO:34334; adherens junction maintenance
GO:1902414; protein localization to cell junction
GO:35505; positive regulation of myosin light chain kinase activity
GO:1902462; positive regulation of mesenchymal stem cell proliferation
GO:1903691; positive regulation of wound healing, spreading of epidermal cells
GO:60173; limb development
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:5856; cytoskeleton
GO:5925; focal adhesion
GO:30054; cell junction
GO:42995; cell projection
GO:5938; cell cortex
GO:9986; cell surface
GO:31258; lamellipodium membrane
GO:31234; extrinsic component of cytoplasmic side of plasma membrane
GO:31674; I band
GO:30055; cell-substrate junction
GO:5912; adherens junction
GO:1725; stress fiber
Function: GO:5515; protein binding
GO:8289; lipid binding
GO:5547; phosphatidylinositol-3,4,5-trisphosphate binding
GO:5178; integrin binding
GO:19901; protein kinase binding
GO:3779; actin binding
GO:34713; type I transforming growth factor beta receptor binding
GO:46332; SMAD binding
GO:51015; actin filament binding
Hide GO terms

Homologs of FERMT2 in Model Organisms

Danio rerio
fermt2
Mus musculus
Fermt2
Rattus norvegicus
Fermt2

External links

OMIM
607746
Ensembl
ENSG00000073712
Entrez Gene
10979
UniGene
509343
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FERMT2
GeneCards
FERMT2