Cell Senescence Entries for FGF21

Cell Types
Bone marrow mesenchymal stem
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Li et al. (2020) FGF21 Mediates Mesenchymal Stem Cell Senescence via Regulation of Mitochondrial Dynamics. Oxid Med Cell Longev 2019(2)4915149 (PubMed)

FGF21 Gene Information

HGNC symbol
FGF21 
Aliases
 
Common name
fibroblast growth factor 21 
Entrez Id
26291
Description
Theis gene encodes a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. This protein is a secreted endocrine factor that functions as a major metabolic regulator. The encoded protein stimulates the uptake of glucose in adipose tissue. [provided by RefSeq, Mar 2016].

FGF21 Ontologies

Gene Ontology
Process: GO:30334; regulation of cell migration
GO:8543; fibroblast growth factor receptor signaling pathway
GO:30154; cell differentiation
GO:9887; animal organ morphogenesis
GO:70374; positive regulation of ERK1 and ERK2 cascade
GO:7165; signal transduction
GO:7267; cell-cell signaling
GO:10628; positive regulation of gene expression
GO:8284; positive regulation of cell population proliferation
GO:120162; positive regulation of cold-induced thermogenesis
GO:1934; positive regulation of protein phosphorylation
And 17 more GO terms
Cellular component: GO:5576; extracellular region
GO:5737; cytoplasm
GO:5615; extracellular space
Function: GO:8083; growth factor activity
GO:5515; protein binding
GO:5104; fibroblast growth factor receptor binding
Show all GO terms

Homologs of FGF21 in Model Organisms

Mus musculus
Fgf21
Rattus norvegicus
Fgf21

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Fgf21
GenAge human genes
  • This gene is present as FGF21

External links

OMIM
609436
Ensembl
ENSG00000105550
Entrez Gene
26291
UniGene
283015
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FGF21
GeneCards
FGF21