Cell Senescence Entries for FGFR1

Cell Types
Breast cancer, Lung carcinoma
Cell Lines
A549, HDF, MCF-7
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Jung et al. (2016) Heparan sulfation is essential for the prevention of cellular senescence. Cell Death Differ 23(3)417-29 (PubMed)

FGFR1 Gene Information

HGNC symbol
FGFR1 
Aliases
BFGFR; CD331; CEK; FLG; FLT2; H2; H3; H4; H5; KAL2; N-SAM 
Common name
fibroblast growth factor receptor 1 
Entrez Id
2260
Description
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].

FGFR1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:8284; positive regulation of cell population proliferation
GO:18108; peptidyl-tyrosine phosphorylation
GO:48513; animal organ development
GO:8543; fibroblast growth factor receptor signaling pathway
GO:71363; cellular response to growth factor stimulus
GO:71495; cellular response to endogenous stimulus
GO:48015; phosphatidylinositol-mediated signaling
GO:46777; protein autophosphorylation
GO:16477; cell migration
GO:43410; positive regulation of MAPK cascade
GO:45595; regulation of cell differentiation
GO:51897; positive regulation of protein kinase B signaling
GO:1501; skeletal system development
GO:7169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:33674; positive regulation of kinase activity
GO:43536; positive regulation of blood vessel endothelial cell migration
GO:1905564; positive regulation of vascular endothelial cell proliferation
GO:14068; positive regulation of phosphatidylinositol 3-kinase signaling
GO:1764; neuron migration
GO:1837; epithelial to mesenchymal transition
GO:43406; positive regulation of MAP kinase activity
GO:10863; positive regulation of phospholipase C activity
GO:165; MAPK cascade
GO:10518; positive regulation of phospholipase activity
GO:43009; chordate embryonic development
GO:45597; positive regulation of cell differentiation
GO:45666; positive regulation of neuron differentiation
GO:48705; skeletal system morphogenesis
GO:2000546; positive regulation of endothelial cell chemotaxis to fibroblast growth factor
GO:2001239; regulation of extrinsic apoptotic signaling pathway in absence of ligand
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:31410; cytoplasmic vesicle
GO:5886; plasma membrane
GO:5829; cytosol
GO:5576; extracellular region
GO:5887; integral component of plasma membrane
GO:43235; receptor complex
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4713; protein tyrosine kinase activity
GO:4714; transmembrane receptor protein tyrosine kinase activity
GO:5007; fibroblast growth factor-activated receptor activity
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:8201; heparin binding
GO:42802; identical protein binding
GO:17134; fibroblast growth factor binding
GO:90722; receptor-receptor interaction
Hide GO terms

Homologs of FGFR1 in Model Organisms

Danio rerio
fgfr1a
Mus musculus
Fgfr1
Rattus norvegicus
Fgfr1

In other databases

GenAge human genes
  • This gene is present as FGFR1
LongevityMap
  • This gene is present as FGFR1

External links

OMIM
136350
Ensembl
ENSG00000077782
Entrez Gene
2260
UniGene
264887
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FGFR1
GeneCards
FGFR1