Cell Senescence Entries for FOS

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Phillips et al. (1992) Renewed DNA synthesis in senescent WI-38 cells by expression of an inducible chimeric c-fos construct. J Cell Physiol 151(1)206-12 (PubMed)

FOS Gene Information

HGNC symbol
FOS 
Aliases
AP-1; c-fos 
Common name
Fos proto-oncogene, AP-1 transcription factor subunit 
Entrez Id
2353
Description
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. In some cases, expression of the FOS gene has also been associated with apoptotic cell death. [provided by RefSeq, Jul 2008].

FOS Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:6954; inflammatory response
GO:45893; positive regulation of transcription, DNA-templated
GO:6366; transcription by RNA polymerase II
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:34614; cellular response to reactive oxygen species
GO:71276; cellular response to cadmium ion
GO:60395; SMAD protein signal transduction
GO:1901216; positive regulation of neuron death
And 29 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5783; endoplasmic reticulum
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5667; transcription regulator complex
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
GO:32993; protein-DNA complex
GO:35976; transcription factor AP-1 complex
GO:16020; membrane
And 2 more GO terms
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:70412; R-SMAD binding
GO:976; transcription cis-regulatory region binding
GO:979; RNA polymerase II core promoter sequence-specific DNA binding
And 7 more GO terms
Show all GO terms

Homologs of FOS in Model Organisms

Danio rerio
fos
Mus musculus
Fos
Rattus norvegicus
Fos

In other databases

GenAge human genes
  • This gene is present as FOS

External links

OMIM
164810
Ensembl
ENSG00000170345
Entrez Gene
2353
UniGene
25647
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FOS
GeneCards
FOS