Cell Senescence Entries for FOXO1

Cell Types
Foreskin fibroblast
Cell Lines
NHDF
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Latorre et al. (2019) FOXO1 and ETV6 genes may represent novel regulators of splicing factor expression in cellular senescence. FASEB J 33(1)1086-1097 (PubMed)

FOXO1 Gene Information

HGNC symbol
FOXO1 
Aliases
FKH1; FKHR; FOXO1A 
Common name
forkhead box O1 
Entrez Id
2308
Description
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008].

FOXO1 Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:6355; regulation of transcription, DNA-templated
GO:6915; apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:30154; cell differentiation
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6914; autophagy
GO:45893; positive regulation of transcription, DNA-templated
GO:43065; positive regulation of apoptotic process
GO:122; negative regulation of transcription by RNA polymerase II
GO:6357; regulation of transcription by RNA polymerase II
GO:6473; protein acetylation
GO:45444; fat cell differentiation
GO:10508; positive regulation of autophagy
GO:9267; cellular response to starvation
GO:45732; positive regulation of protein catabolic process
GO:34599; cellular response to oxidative stress
GO:8286; insulin receptor signaling pathway
GO:45599; negative regulation of fat cell differentiation
GO:1678; cellular glucose homeostasis
GO:32869; cellular response to insulin stimulus
GO:97009; energy homeostasis
GO:70542; response to fatty acid
GO:1659; temperature homeostasis
GO:71455; cellular response to hyperoxia
GO:1903243; negative regulation of cardiac muscle hypertrophy in response to stress
GO:32873; negative regulation of stress-activated MAPK cascade
GO:71732; cellular response to nitric oxide
GO:1568; blood vessel development
GO:6111; regulation of gluconeogenesis
GO:42127; regulation of cell population proliferation
GO:42593; glucose homeostasis
GO:45722; positive regulation of gluconeogenesis
GO:70417; cellular response to cold
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:97150; neuronal stem cell population maintenance
GO:2000177; regulation of neural precursor cell proliferation
GO:2000377; regulation of reactive oxygen species metabolic process
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5739; mitochondrion
GO:5829; cytosol
GO:785; chromatin
GO:5654; nucleoplasm
Function: GO:3677; DNA binding
GO:31625; ubiquitin protein ligase binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:3682; chromatin binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:8013; beta-catenin binding
GO:51721; protein phosphatase 2A binding
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:31490; chromatin DNA binding
GO:1990841; promoter-specific chromatin binding
Hide GO terms

Homologs of FOXO1 in Model Organisms

Danio rerio
foxo1b
Mus musculus
Foxo1
Rattus norvegicus
Foxo1

In other databases

GenAge human genes
  • This gene is present as FOXO1
LongevityMap
  • This gene is present as FOXO1

External links

OMIM
136533
Ensembl
ENSG00000150907
Entrez Gene
2308
UniGene
370666
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FOXO1
GeneCards
FOXO1