Cell Senescence Entries for FSCN1

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Osanai et al. (2016) The retinoic acid-metabolizing enzyme CYP26A1 upregulates fascin and promotes the malignant behavior of breast carcinoma cells. Oncol Rep 34(2)850-8 (PubMed)

FSCN1 Gene Information

HGNC symbol
FSCN1 
Aliases
FLJ38511; p55; SNL 
Common name
fascin actin-bundling protein 1 
Entrez Id
6624
Description
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011].

FSCN1 Ontologies

Gene Ontology
Process: GO:7015; actin filament organization
GO:30036; actin cytoskeleton organization
GO:16477; cell migration
GO:51017; actin filament bundle assembly
GO:51491; positive regulation of filopodium assembly
GO:32956; regulation of actin cytoskeleton organization
GO:7163; establishment or maintenance of cell polarity
GO:7043; cell-cell junction assembly
GO:32534; regulation of microvillus assembly
GO:10592; positive regulation of lamellipodium assembly
GO:30035; microspike assembly
And 6 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
GO:5856; cytoskeleton
GO:30054; cell junction
GO:30175; filopodium
GO:42995; cell projection
GO:5938; cell cortex
GO:30027; lamellipodium
GO:1726; ruffle
GO:30426; growth cone
GO:5902; microvillus
And 8 more GO terms
Function: GO:3723; RNA binding
GO:3779; actin binding
GO:51015; actin filament binding
GO:5515; protein binding
GO:30674; protein-macromolecule adaptor activity
GO:45296; cadherin binding
Show all GO terms

Homologs of FSCN1 in Model Organisms

Danio rerio
fscn1a
Mus musculus
Fscn1
Rattus norvegicus
Fscn1

External links

OMIM
602689
Ensembl
ENSG00000075618
Entrez Gene
6624
UniGene
118400
1000 Genomes
1000 Genomes
HPRD
GenAtlas
FSCN1
GeneCards
FSCN1