Cell Senescence Entries for GAPDH

Cell Types
Lung cancer
Cell Lines
A549
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Phadke et al. (2011) Accelerated cellular senescence phenotype of GAPDH-depleted human lung carcinoma cells. Biochem Biophys Res Commun 411(2)409-15 (PubMed)

GAPDH Gene Information

HGNC symbol
GAPDH 
Aliases
GAPD 
Common name
glyceraldehyde-3-phosphate dehydrogenase 
Entrez Id
2597
Description
This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014].

GAPDH Ontologies

Gene Ontology
Process: GO:6915; apoptotic process
GO:6096; glycolytic process
GO:6417; regulation of translation
GO:17148; negative regulation of translation
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:2376; immune system process
GO:45087; innate immune response
GO:6006; glucose metabolic process
GO:50821; protein stabilization
GO:1819; positive regulation of cytokine production
GO:71346; cellular response to interferon-gamma
GO:61844; antimicrobial humoral immune response mediated by antimicrobial peptide
GO:226; microtubule cytoskeleton organization
GO:51402; neuron apoptotic process
GO:31640; killing of cells of other organism
GO:16241; regulation of macroautophagy
GO:32481; positive regulation of type I interferon production
GO:10951; negative regulation of endopeptidase activity
GO:51873; killing by host of symbiont cells
GO:50832; defense response to fungus
GO:35606; peptidyl-cysteine S-trans-nitrosylation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:43231; intracellular membrane-bounded organelle
GO:5829; cytosol
GO:5886; plasma membrane
GO:5856; cytoskeleton
GO:31965; nuclear membrane
GO:1990904; ribonucleoprotein complex
GO:48471; perinuclear region of cytoplasm
GO:31982; vesicle
GO:5811; lipid droplet
GO:15630; microtubule cytoskeleton
GO:70062; extracellular exosome
GO:97452; GAIT complex
Function: GO:166; nucleotide binding
GO:16740; transferase activity
GO:16491; oxidoreductase activity
GO:50661; NADP binding
GO:51287; NAD binding
GO:5515; protein binding
GO:16620; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:8017; microtubule binding
GO:42802; identical protein binding
GO:4365; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:97718; disordered domain specific binding
GO:19828; aspartic-type endopeptidase inhibitor activity
GO:35605; peptidyl-cysteine S-nitrosylase activity
Hide GO terms

Homologs of GAPDH in Model Organisms

Caenorhabditis elegans
gpd-4
Danio rerio
gapdh
Drosophila melanogaster
Gapdh2
Mus musculus
Gm6316
Rattus norvegicus
RGD1562758
Schizosaccharomyces pombe
tdh1

External links

OMIM
138400
Ensembl
ENSG00000111640
Entrez Gene
2597
UniGene
592355
1000 Genomes
1000 Genomes
HPRD
GenAtlas
GAPDH
GeneCards
GAPDH