Cell Senescence Entries for GJA1

Cell Types
Chondrocyte
Cell Lines
T/C-28a2
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Varela-Eirín et al. (2019) Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis. Cell Death Dis 9(12)1166 (PubMed)

GJA1 Gene Information

HGNC symbol
GJA1 
Aliases
CX43; GJAL; ODD; ODDD; ODOD; SDTY3 
Common name
gap junction protein alpha 1 
Entrez Id
2697
Description
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations. [provided by RefSeq, May 2014].

GJA1 Ontologies

Gene Ontology
Process: GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:60348; bone development
GO:7154; cell communication
GO:7283; spermatogenesis
GO:7507; heart development
GO:7267; cell-cell signaling
GO:34775; glutathione transmembrane transport
GO:30308; negative regulation of cell growth
GO:10628; positive regulation of gene expression
GO:1904646; cellular response to amyloid-beta
GO:35633; maintenance of blood-brain barrier
And 49 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:43231; intracellular membrane-bounded organelle
GO:5783; endoplasmic reticulum
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:5925; focal adhesion
GO:30054; cell junction
GO:16324; apical plasma membrane
GO:5921; gap junction
And 18 more GO terms
Function: GO:22857; transmembrane transporter activity
GO:5515; protein binding
GO:5243; gap junction channel activity
GO:15631; tubulin binding
GO:15562; efflux transmembrane transporter activity
GO:34634; glutathione transmembrane transporter activity
GO:8013; beta-catenin binding
GO:15075; ion transmembrane transporter activity
GO:55077; gap junction hemi-channel activity
GO:86075; gap junction channel activity involved in cardiac conduction electrical coupling
GO:1903763; gap junction channel activity involved in cell communication by electrical coupling
And 5 more GO terms
Show all GO terms

Homologs of GJA1 in Model Organisms

Danio rerio
gja1
Mus musculus
Gja1
Rattus norvegicus
Gja1

External links

OMIM
121014
Ensembl
ENSG00000152661
Entrez Gene
2697
UniGene
700699
1000 Genomes
1000 Genomes
HPRD
GenAtlas
GJA1
GeneCards
GJA1