Cell Senescence Entries for GMNN

Cell Types
Gingival fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Iliou et al. (2013) Reduced Geminin levels promote cellular senescence. Mech Ageing Dev 134(1-2)10-23 (PubMed)

GMNN Gene Information

HGNC symbol
GMNN 
Aliases
Gem 
Common name
geminin DNA replication inhibitor 
Entrez Id
51053
Description
This gene encodes a protein that plays a critical role in cell cycle regulation. The encoded protein inhibits DNA replication by binding to DNA replication factor Cdt1, preventing the incorporation of minichromosome maintenance proteins into the pre-replication complex. The encoded protein is expressed during the S and G2 phases of the cell cycle and is degraded by the anaphase-promoting complex during the metaphase-anaphase transition. Increased expression of this gene may play a role in several malignancies including colon, rectal and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and two pseudogenes of this gene are located on the short arm of chromosome 16. [provided by RefSeq, Oct 2011].

GMNN Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:45892; negative regulation of transcription, DNA-templated
GO:6275; regulation of DNA replication
GO:8156; negative regulation of DNA replication
GO:45786; negative regulation of cell cycle
GO:7346; regulation of mitotic cell cycle
GO:30174; regulation of DNA-dependent DNA replication initiation
GO:35563; positive regulation of chromatin binding
GO:71163; DNA replication preinitiation complex assembly
GO:2000104; negative regulation of DNA-dependent DNA replication
GO:9887; animal organ morphogenesis
And 2 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:17053; transcription repressor complex
Function: GO:5515; protein binding
GO:42826; histone deacetylase binding
GO:3682; chromatin binding
GO:3714; transcription corepressor activity
GO:140297; DNA-binding transcription factor binding
Show all GO terms

Homologs of GMNN in Model Organisms

Danio rerio
gmnn
Drosophila melanogaster
geminin
Mus musculus
Gmnn
Rattus norvegicus
Gmnn

In other databases

CellAge gene expression
  • This gene is present as GMNN

External links

OMIM
602842
Ensembl
ENSG00000112312
Entrez Gene
51053
UniGene
234896
1000 Genomes
1000 Genomes
HPRD
GenAtlas
GMNN
GeneCards
GMNN