Cell Senescence Entries for GRIK2

Cell Types
Ovarian cancer
Cell Lines
SKOV3
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Zhawar et al. (2019) Isoforms of Ionotropic Glutamate Receptor GRIK2 Induce Senescence of Carcinoma Cells. Cancer Genomics Proteomics 16(1)59-64 (PubMed)

GRIK2 Gene Information

HGNC symbol
GRIK2 
Aliases
GluK2; GLUR6; MRT6 
Common name
glutamate ionotropic receptor kainate type subunit 2 
Entrez Id
2898
Description
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing at multiple sites within the first and second transmembrane domains, which is thought to alter the structure and function of the receptor complex. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. Mutations in this gene have been associated with autosomal recessive cognitive disability. [provided by RefSeq, Jul 2008].

GRIK2 Ontologies

Gene Ontology
Process: GO:6811; ion transport
GO:34220; ion transmembrane transport
GO:99505; regulation of presynaptic membrane potential
GO:35235; ionotropic glutamate receptor signaling pathway
GO:48172; regulation of short-term neuronal synaptic plasticity
GO:7268; chemical synaptic transmission
GO:35249; synaptic transmission, glutamatergic
GO:7215; glutamate receptor signaling pathway
GO:50804; modulation of chemical synaptic transmission
GO:50806; positive regulation of synaptic transmission
GO:120169; detection of cold stimulus involved in thermoception
And 10 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:30054; cell junction
GO:45202; synapse
GO:45211; postsynaptic membrane
GO:5887; integral component of plasma membrane
GO:42734; presynaptic membrane
GO:32983; kainate selective glutamate receptor complex
GO:110165; cellular anatomical entity
GO:14069; postsynaptic density
And 4 more GO terms
Function: GO:38023; signaling receptor activity
GO:15276; ligand-gated ion channel activity
GO:5216; ion channel activity
GO:4970; ionotropic glutamate receptor activity
GO:8066; glutamate receptor activity
GO:1904315; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
GO:15277; kainate selective glutamate receptor activity
GO:5234; extracellularly glutamate-gated ion channel activity
GO:99507; ligand-gated ion channel activity involved in regulation of presynaptic membrane potential
Show all GO terms

Homologs of GRIK2 in Model Organisms

Danio rerio
grik2
Mus musculus
Grik2
Rattus norvegicus
Grik2

External links

OMIM
138244
Ensembl
ENSG00000164418
Entrez Gene
2898
UniGene
98262
1000 Genomes
1000 Genomes
HPRD
GenAtlas
GRIK2
GeneCards
GRIK2