Cell Senescence Entries for GRK6

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

GRK6 Gene Information

HGNC symbol
GRK6 
Aliases
GPRK6 
Common name
G protein-coupled receptor kinase 6 
Entrez Id
2870
Description
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].

GRK6 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:7165; signal transduction
GO:16055; Wnt signaling pathway
GO:7186; G protein-coupled receptor signaling pathway
GO:8277; regulation of G protein-coupled receptor signaling pathway
GO:9966; regulation of signal transduction
Cellular component: GO:16020; membrane
GO:5737; cytoplasm
GO:5886; plasma membrane
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4703; G protein-coupled receptor kinase activity
GO:5515; protein binding
GO:47696; beta-adrenergic receptor kinase activity
Show all GO terms

Homologs of GRK6 in Model Organisms

Danio rerio
grk6
Mus musculus
Grk6
Rattus norvegicus
Grk6

External links

OMIM
600869
Ensembl
ENSG00000198055
Entrez Gene
2870
UniGene
235116
1000 Genomes
1000 Genomes
HPRD
GenAtlas
GRK6
GeneCards
GRK6