Cell Senescence Entries for GRPR

Cell Types
Glioblastoma
Cell Lines
A172
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Menegotto et al. (2018) Gastrin-Releasing Peptide Receptor Knockdown Induces Senescence in Glioblastoma Cells. Mol Neurobiol 54(2)888-894 (PubMed)

GRPR Gene Information

HGNC symbol
GRPR 
Aliases
BB2; BB2R; BRS2 
Common name
gastrin releasing peptide receptor 
Entrez Id
2925
Description
Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008].

GRPR Ontologies

Gene Ontology
Process: GO:7186; G protein-coupled receptor signaling pathway
GO:7165; signal transduction
GO:7218; neuropeptide signaling pathway
GO:35176; social behavior
GO:7200; phospholipase C-activating G protein-coupled receptor signaling pathway
GO:7611; learning or memory
GO:36343; psychomotor behavior
GO:42127; regulation of cell population proliferation
GO:43207; response to external biotic stimulus
GO:61744; motor behavior
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:5887; integral component of plasma membrane
Function: GO:4930; G protein-coupled receptor activity
GO:8188; neuropeptide receptor activity
GO:8528; G protein-coupled peptide receptor activity
GO:42923; neuropeptide binding
Show all GO terms

Homologs of GRPR in Model Organisms

Danio rerio
grpr
Mus musculus
Grpr
Rattus norvegicus
Grpr

External links

OMIM
305670
Ensembl
ENSG00000126010
Entrez Gene
2925
UniGene
567282
1000 Genomes
1000 Genomes
HPRD
GenAtlas
GRPR
GeneCards
GRPR