Cell Senescence Entries for GRSF1

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Kim et al. (2020) GRSF1 is an age-related regulator of senescence. Sci Rep 9(1)5546 (PubMed)

GRSF1 Gene Information

HGNC symbol
GRSF1 
Aliases
 
Common name
G-rich RNA sequence binding factor 1 
Entrez Id
2926
Description
The protein encoded by this gene is a cellular protein that binds RNAs containing the G-rich element. The protein is localized in the cytoplasm, and has been shown to stimulate translation of viral mRNAs in vitro. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

GRSF1 Ontologies

Gene Ontology
Process: GO:6396; RNA processing
GO:6397; mRNA processing
GO:8033; tRNA processing
GO:43484; regulation of RNA splicing
GO:962; positive regulation of mitochondrial RNA catabolic process
GO:6378; mRNA polyadenylation
GO:9952; anterior/posterior pattern specification
GO:16331; morphogenesis of embryonic epithelium
Cellular component: GO:5737; cytoplasm
GO:5739; mitochondrion
GO:5759; mitochondrial matrix
GO:5654; nucleoplasm
GO:42645; mitochondrial nucleoid
GO:1990904; ribonucleoprotein complex
GO:35770; ribonucleoprotein granule
Function: GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:5515; protein binding
GO:3729; mRNA binding
Show all GO terms

Homologs of GRSF1 in Model Organisms

Caenorhabditis elegans
hrpf-2
Mus musculus
Grsf1
Rattus norvegicus
Grsf1

External links

OMIM
604851
Ensembl
ENSG00000132463
Entrez Gene
2926
UniGene
309763
1000 Genomes
1000 Genomes
HPRD
GenAtlas
GRSF1
GeneCards
GRSF1