Cell Senescence Entries for GSK3A

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Kim et al. (2014) Glycogen Synthase Kinase 3 Inactivation Induces Cell Senescence through Sterol Regulatory Element Binding Protein 1-Mediated Lipogenesis in Chang Cells. Endocrinol Metab (Seoul) 28(4)297-308 (PubMed)

GSK3A Gene Information

HGNC symbol
GSK3A 
Aliases
 
Common name
glycogen synthase kinase 3 alpha 
Entrez Id
2931
Description
This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011].

GSK3A Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:5975; carbohydrate metabolic process
GO:9968; negative regulation of signal transduction
GO:5977; glycogen metabolic process
GO:16055; Wnt signaling pathway
GO:51093; negative regulation of developmental process
GO:51128; regulation of cellular component organization
GO:16310; phosphorylation
GO:7399; nervous system development
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:90090; negative regulation of canonical Wnt signaling pathway
And 36 more GO terms
Cellular component: GO:5739; mitochondrion
GO:5634; nucleus
GO:5737; cytoplasm
GO:98794; postsynapse
GO:5829; cytosol
GO:30424; axon
GO:43025; neuronal cell body
GO:30877; beta-catenin destruction complex
GO:1990635; proximal dendrite
GO:97440; apical dendrite
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:5524; ATP binding
GO:16740; transferase activity
GO:50321; tau-protein kinase activity
GO:5515; protein binding
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:106310; protein serine kinase activity
GO:5102; signaling receptor binding
And 3 more GO terms
Show all GO terms

Homologs of GSK3A in Model Organisms

Caenorhabditis elegans
gsk-3
Danio rerio
gsk3aa
Mus musculus
Gsk3a
Rattus norvegicus
Gsk3a
Schizosaccharomyces pombe
gsk3

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Gsk3a
  • A homolog of this gene for Schizosaccharomyces pombe is present as gsk3
GenAge human genes
  • This gene is present as GSK3A

External links

OMIM
606784
Ensembl
ENSG00000105723
Entrez Gene
2931
UniGene
466828
1000 Genomes
1000 Genomes
HPRD
GenAtlas
GSK3A
GeneCards
GSK3A