Cell Senescence Entries for GSK3B

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Knockdown, Mutation
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Seo et al. (2009) Enhanced glycogenesis is involved in cellular senescence via GSK3/GS modulation. Aging Cell 7(6)894-907 (PubMed)

GSK3B Gene Information

HGNC symbol
GSK3B 
Aliases
 
Common name
glycogen synthase kinase 3 beta 
Entrez Id
2932
Description
The protein encoded by this gene is a serine-threonine kinase belonging to the glycogen synthase kinase subfamily. It is a negative regulator of glucose homeostasis and is involved in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways. Defects in this gene have been associated with Parkinson disease and Alzheimer disease. [provided by RefSeq, Aug 2017].

GSK3B Ontologies

Gene Ontology
Process: GO:10629; negative regulation of gene expression
GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:5975; carbohydrate metabolic process
GO:30154; cell differentiation
GO:9968; negative regulation of signal transduction
GO:5977; glycogen metabolic process
GO:16055; Wnt signaling pathway
GO:51093; negative regulation of developmental process
GO:51128; regulation of cellular component organization
GO:7399; nervous system development
And 71 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:16020; membrane
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:5739; mitochondrion
GO:5813; centrosome
GO:98794; postsynapse
GO:5829; cytosol
GO:30424; axon
GO:30877; beta-catenin destruction complex
And 5 more GO terms
Function: GO:5515; protein binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:50321; tau-protein kinase activity
GO:19901; protein kinase binding
And 10 more GO terms
Show all GO terms

Homologs of GSK3B in Model Organisms

Danio rerio
gsk3b
Drosophila melanogaster
sgg
Mus musculus
Gsk3b
Rattus norvegicus
Gsk3b
Saccharomyces cerevisiae
MRK1

In other databases

GenAge human genes
  • This gene is present as GSK3B

External links

OMIM
605004
Ensembl
ENSG00000082701
Entrez Gene
2932
UniGene
445733
1000 Genomes
1000 Genomes
HPRD
GenAtlas
GSK3B
GeneCards
GSK3B