Cell Senescence Entries for HIRA
- Cell Types
- Lung fibroblast
- Cell Lines
- WI-38
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Zhang et al. (2005) Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell 8(1)19-30 (PubMed)
HIRA Gene Information
- HGNC symbol
- HIRA
- Aliases
- DGCR1; TUP1; TUPLE1
- Common name
- histone cell cycle regulator
- Entrez Id
- 7290
- Description
- This gene encodes a histone chaperone that preferentially places the variant histone H3.3 in nucleosomes. Orthologs of this gene in yeast, flies, and plants are necessary for the formation of transcriptionally silent heterochomatin. This gene plays an important role in the formation of the senescence-associated heterochromatin foci. These foci likely mediate the irreversible cell cycle changes that occur in senescent cells. It is considered the primary candidate gene in some haploinsufficiency syndromes such as DiGeorge syndrome, and insufficient production of the gene may disrupt normal embryonic development. [provided by RefSeq, Jul 2008].
HIRA Ontologies
- Gene Ontology
-
Process: GO:6355; regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:6351; transcription, DNA-templated
GO:45892; negative regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:9653; anatomical structure morphogenesis
GO:6336; DNA replication-independent nucleosome assembly
GO:1649; osteoblast differentiation
GO:7369; gastrulation
GO:42692; muscle cell differentiation
Cellular component: GO:5634; nucleus
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:785; chromatin
GO:16605; PML body
GO:70062; extracellular exosome
GO:417; HIR complex
Show all GO termsFunction: GO:5515; protein binding
GO:3714; transcription corepressor activity
GO:31491; nucleosome binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:42393; histone binding
Homologs of HIRA in Model Organisms
- Caenorhabditis elegans
- K10D2.1
- Danio rerio
- hira
- Drosophila melanogaster
- Hira
- Mus musculus
- Hira
- Rattus norvegicus
- LOC100911837
- Saccharomyces cerevisiae
- HIR2
- Schizosaccharomyces pombe
- hip1
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as HIR2
External links
- OMIM
- 600237
- Ensembl
- ENSG00000100084
- Entrez Gene
- 7290
- UniGene
- 474206
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- HIRA
- GeneCards
- HIRA