Cell Senescence Entries for HK3

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

HK3 Gene Information

HGNC symbol
HK3 
Aliases
 
Common name
hexokinase 3 
Entrez Id
3101
Description
Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6-phosphate. [provided by RefSeq, Apr 2009].

HK3 Ontologies

Gene Ontology
Process: GO:16310; phosphorylation
GO:6096; glycolytic process
GO:1678; cellular glucose homeostasis
GO:5975; carbohydrate metabolic process
GO:19318; hexose metabolic process
GO:46835; carbohydrate phosphorylation
GO:51156; glucose 6-phosphate metabolic process
GO:8152; metabolic process
GO:6002; fructose 6-phosphate metabolic process
GO:61621; canonical glycolysis
Cellular component: GO:5576; extracellular region
GO:5739; mitochondrion
GO:5829; cytosol
GO:34774; secretory granule lumen
GO:1904813; ficolin-1-rich granule lumen
Function: GO:166; nucleotide binding
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4340; glucokinase activity
GO:4396; hexokinase activity
GO:5536; glucose binding
GO:16773; phosphotransferase activity, alcohol group as acceptor
GO:3824; catalytic activity
GO:5515; protein binding
GO:8865; fructokinase activity
And 2 more GO terms
Show all GO terms

Homologs of HK3 in Model Organisms

Caenorhabditis elegans
CELE_H25P06.1
Mus musculus
Hk3
Rattus norvegicus
Hk3

External links

OMIM
142570
Ensembl
ENSG00000160883
Entrez Gene
3101
UniGene
411695
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HK3
GeneCards
HK3