Cell Senescence Entries for HMGA2

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Narita et al. (2006) A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation. Cell 126(3)503-14 (PubMed)

HMGA2 Gene Information

HGNC symbol
HMGA2 
Aliases
BABL; HMGIC; LIPO 
Common name
high mobility group AT-hook 2 
Entrez Id
8091
Description
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

HMGA2 Ontologies

Gene Ontology
Process: GO:2000773; negative regulation of cellular senescence
GO:7049; cell cycle
GO:43066; negative regulation of apoptotic process
GO:6355; regulation of transcription, DNA-templated
GO:45892; negative regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:51301; cell division
GO:45944; positive regulation of transcription by RNA polymerase II
GO:30261; chromosome condensation
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
And 32 more GO terms
Cellular component: GO:5634; nucleus
GO:785; chromatin
GO:228; nuclear chromosome
GO:5654; nucleoplasm
GO:32993; protein-DNA complex
GO:35985; senescence-associated heterochromatin focus
GO:71141; SMAD protein complex
Function: GO:3677; DNA binding
GO:5515; protein binding
GO:976; transcription cis-regulatory region binding
GO:3714; transcription corepressor activity
GO:3906; DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:3712; transcription coregulator activity
GO:8301; DNA binding, bending
GO:31492; nucleosomal DNA binding
GO:51575; 5'-deoxyribose-5-phosphate lyase activity
GO:46332; SMAD binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
And 6 more GO terms
Show all GO terms

Homologs of HMGA2 in Model Organisms

Danio rerio
hmga2
Mus musculus
Hmga2
Rattus norvegicus
Hmga2

In other databases

CellAge gene expression
  • This gene is present as HMGA2

External links

OMIM
600698
Ensembl
ENSG00000149948
Entrez Gene
8091
UniGene
666976
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HMGA2
GeneCards
HMGA2