Cell Senescence Entries for HMGB1

Cell Types
Lung cancer, Melanoma
Cell Lines
A375, G361, NCI-H1299, SK-MEL-28
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Li et al. (2015) Overexpression of HMGB1 in melanoma predicts patient survival and suppression of HMGB1 induces cell cycle arrest and senescence in association with p21 (Waf1/Cip1) up-regulation via a p53-independent, Sp1-dependent pathway. Oncotarget 5(15)6387-403 (PubMed)

HMGB1 Gene Information

HGNC symbol
HMGB1 
Aliases
DKFZp686A04236; HMG1; HMG3; SBP-1 
Common name
high mobility group box 1 
Entrez Id
3146
Description
This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015].

HMGB1 Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:6935; chemotaxis
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6914; autophagy
GO:6310; DNA recombination
GO:122; negative regulation of transcription by RNA polymerase II
GO:2376; immune system process
GO:45087; innate immune response
GO:43065; positive regulation of apoptotic process
And 52 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5886; plasma membrane
GO:5768; endosome
GO:5576; extracellular region
GO:5694; chromosome
GO:5615; extracellular space
GO:793; condensed chromosome
GO:9986; cell surface
GO:5793; endoplasmic reticulum-Golgi intermediate compartment
And 6 more GO terms
Function: GO:3723; RNA binding
GO:3677; DNA binding
GO:16829; lyase activity
GO:5515; protein binding
GO:5125; cytokine activity
GO:3684; damaged DNA binding
GO:3713; transcription coactivator activity
GO:400; four-way junction DNA binding
GO:405; bubble DNA binding
GO:8301; DNA binding, bending
GO:97100; supercoiled DNA binding
And 14 more GO terms
Show all GO terms

Homologs of HMGB1 in Model Organisms

Mus musculus
Hmgb1
Rattus norvegicus
LOC685520

In other databases

GenAge human genes
  • This gene is present as HMGB1
LongevityMap
  • This gene is present as HMGB1
CellAge gene expression
  • This gene is present as HMGB1

External links

OMIM
163905
Ensembl
ENSG00000189403
Entrez Gene
3146
UniGene
593339
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HMGB1
GeneCards
HMGB1