Cell Senescence Entries for HNRNPA1

Cell Types
Adenocarcinoma, Umbilical vein endothelial
Cell Lines
A549, HUVEC
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Jia et al. (2020) HNRNPA1-mediated 3' UTR length changes of HN1 contributes to cancer- and senescence-associated phenotypes. Aging (Albany NY) 11(13)4407-4437 (PubMed)

HNRNPA1 Gene Information

HGNC symbol
HNRNPA1 
Aliases
ALS20; hnRNP-A1; HNRPA1 
Common name
heterogeneous nuclear ribonucleoprotein A1 
Entrez Id
3178
Description
This gene encodes a member of a family of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs), which are RNA-binding proteins that associate with pre-mRNAs in the nucleus and influence pre-mRNA processing, as well as other aspects of mRNA metabolism and transport. The protein encoded by this gene is one of the most abundant core proteins of hnRNP complexes and plays a key role in the regulation of alternative splicing. Mutations in this gene have been observed in individuals with amyotrophic lateral sclerosis 20. Multiple alternatively spliced transcript variants have been found. There are numerous pseudogenes of this gene distributed throughout the genome. [provided by RefSeq, Feb 2016].

HNRNPA1 Ontologies

Gene Ontology
Process: GO:6397; mRNA processing
GO:8380; RNA splicing
GO:51028; mRNA transport
GO:43484; regulation of RNA splicing
GO:398; mRNA splicing, via spliceosome
GO:32212; positive regulation of telomere maintenance via telomerase
GO:1903936; cellular response to sodium arsenite
GO:32211; negative regulation of telomere maintenance via telomerase
GO:381; regulation of alternative mRNA splicing, via spliceosome
GO:6405; RNA export from nucleus
GO:42149; cellular response to glucose starvation
And 3 more GO terms
Cellular component: GO:5634; nucleus
GO:5681; spliceosomal complex
GO:5737; cytoplasm
GO:16020; membrane
GO:5654; nucleoplasm
GO:1990904; ribonucleoprotein complex
GO:71013; catalytic step 2 spliceosome
GO:70062; extracellular exosome
Function: GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:5515; protein binding
GO:42802; identical protein binding
GO:19904; protein domain specific binding
GO:61752; telomeric repeat-containing RNA binding
GO:36002; pre-mRNA binding
GO:3697; single-stranded DNA binding
GO:3727; single-stranded RNA binding
GO:35198; miRNA binding
GO:98505; G-rich strand telomeric DNA binding
And 1 more GO terms
Show all GO terms

Homologs of HNRNPA1 in Model Organisms

Saccharomyces cerevisiae
HRP1

In other databases

CellAge gene expression

External links

OMIM
164017
Ensembl
ENSG00000135486
Entrez Gene
3178
UniGene
655424
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HNRNPA1
GeneCards
HNRNPA1