Cell Senescence Entries for HNRNPC

Cell Types
Lung cancer
Cell Lines
H358
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Mulnix et al. (2013) hnRNP C1/C2 and Pur-beta proteins mediate induction of senescence by oligonucleotides homologous to the telomere overhang. Onco Targets Ther 7(2)23-32 (PubMed)

HNRNPC Gene Information

HGNC symbol
HNRNPC 
Aliases
HNRPC 
Common name
heterogeneous nuclear ribonucleoprotein C 
Entrez Id
3183
Description
This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene can act as a tetramer and is involved in the assembly of 40S hnRNP particles. Multiple transcript variants encoding at least two different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].

HNRNPC Ontologies

Gene Ontology
Process: GO:6397; mRNA processing
GO:8380; RNA splicing
GO:398; mRNA splicing, via spliceosome
GO:6338; chromatin remodeling
GO:1649; osteoblast differentiation
GO:32211; negative regulation of telomere maintenance via telomerase
GO:70935; 3'-UTR-mediated mRNA stabilization
Cellular component: GO:5697; telomerase holoenzyme complex
GO:5634; nucleus
GO:5681; spliceosomal complex
GO:16020; membrane
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5829; cytosol
GO:785; chromatin
GO:71013; catalytic step 2 spliceosome
GO:70062; extracellular exosome
GO:15629; actin cytoskeleton
And 2 more GO terms
Function: GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:5515; protein binding
GO:1990247; N6-methyladenosine-containing RNA binding
GO:42802; identical protein binding
GO:3730; mRNA 3'-UTR binding
GO:70034; telomerase RNA binding
GO:31492; nucleosomal DNA binding
GO:8266; poly(U) RNA binding
Show all GO terms

Homologs of HNRNPC in Model Organisms

Mus musculus
Hnrnpc

In other databases

CellAge gene expression
  • This gene is present as HNRNPC

External links

OMIM
164020
Ensembl
ENSG00000092199
Entrez Gene
3183
UniGene
675546
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HNRNPC
GeneCards
HNRNPC