Cell Senescence Entries for HOXA9

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Martin et al. (2013) Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK⁴a regulation. EMBO J 32(7)982-95 (PubMed)

HOXA9 Gene Information

HGNC symbol
HOXA9 
Aliases
HOX1; HOX1G 
Common name
homeobox A9 
Entrez Id
3205
Description
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream homeobox A10 (HOXA10) gene.[provided by RefSeq, Mar 2011].

HOXA9 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6351; transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:9952; anterior/posterior pattern specification
GO:45638; negative regulation of myeloid cell differentiation
GO:42118; endothelial cell activation
GO:48704; embryonic skeletal system morphogenesis
GO:7275; multicellular organism development
GO:9954; proximal/distal pattern formation
GO:35195; gene silencing by miRNA
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:785; chromatin
Function: GO:3677; DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:5515; protein binding
GO:19899; enzyme binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:3700; DNA-binding transcription factor activity
GO:1990837; sequence-specific double-stranded DNA binding
Show all GO terms

Homologs of HOXA9 in Model Organisms

Mus musculus
Hoxa9
Rattus norvegicus
Hoxa9

External links

OMIM
142956
Ensembl
ENSG00000078399
Entrez Gene
3205
UniGene
659350
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HOXA9
GeneCards
HOXA9