Cell Senescence Entries for HS2ST1
- Cell Types
- Breast cancer
- Cell Lines
- MCF-7
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Jung et al. (2016) Heparan sulfation is essential for the prevention of cellular senescence. Cell Death Differ 23(3)417-29 (PubMed)
HS2ST1 Gene Information
- HGNC symbol
- HS2ST1
- Aliases
- KIAA0448
- Common name
- heparan sulfate 2-O-sulfotransferase 1
- Entrez Id
- 9653
- Description
- Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Aug 2008].
HS2ST1 Ontologies
- Gene Ontology
-
Process: GO:6024; glycosaminoglycan biosynthetic process
GO:15015; heparan sulfate proteoglycan biosynthetic process, enzymatic modification
GO:15014; heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5794; Golgi apparatus
GO:139; Golgi membrane
GO:98791; Golgi apparatus subcompartment
Show all GO termsFunction: GO:16740; transferase activity
GO:8146; sulfotransferase activity
GO:4394; heparan sulfate 2-O-sulfotransferase activity
GO:5515; protein binding
Homologs of HS2ST1 in Model Organisms
- Caenorhabditis elegans
- hst-2
- Danio rerio
- hs2st1a
- Drosophila melanogaster
- Hs2st
- Mus musculus
- Hs2st1
- Rattus norvegicus
- Hs2st1
External links
- OMIM
- 604844
- Ensembl
- ENSG00000153936
- Entrez Gene
- 9653
- UniGene
- 743280
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- HS2ST1
- GeneCards
- HS2ST1