Cell Senescence Entries for HSPA5
- Cell Types
- Ovarian cancer
- Cell Lines
- A2780
- Cancer Cell?
- Yes
- Method
- Knockout, Overexpression
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Li et al. (2014) Cisplatin-induced senescence in ovarian cancer cells is mediated by GRP78. Oncol Rep 31(6)2525-34 (PubMed)
HSPA5 Gene Information
- HGNC symbol
- HSPA5
- Aliases
- BiP; GRP78
- Common name
- heat shock protein family A (Hsp70) member 5
- Entrez Id
- 3309
- Description
- The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers. [provided by RefSeq, Jul 2020].
HSPA5 Ontologies
- Gene Ontology
-
Process: GO:43066; negative regulation of apoptotic process
GO:30433; ubiquitin-dependent ERAD pathway
GO:30335; positive regulation of cell migration
GO:21762; substantia nigra development
GO:31333; negative regulation of protein-containing complex assembly
GO:42149; cellular response to glucose starvation
GO:1990440; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:51085; chaperone cofactor-dependent protein refolding
GO:30968; endoplasmic reticulum unfolded protein response
GO:1903895; negative regulation of IRE1-mediated unfolded protein response
GO:34620; cellular response to unfolded protein
And 33 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:32991; protein-containing complex
GO:5783; endoplasmic reticulum
GO:43231; intracellular membrane-bounded organelle
GO:5739; mitochondrion
GO:5925; focal adhesion
GO:5829; cytosol
GO:5788; endoplasmic reticulum lumen
GO:42470; melanosome
And 11 more GO terms
Show all GO termsFunction: GO:166; nucleotide binding
GO:5524; ATP binding
GO:16787; hydrolase activity
GO:31625; ubiquitin protein ligase binding
GO:5509; calcium ion binding
GO:5515; protein binding
GO:16887; ATP hydrolysis activity
GO:51082; unfolded protein binding
GO:19904; protein domain specific binding
GO:45296; cadherin binding
GO:19899; enzyme binding
And 6 more GO terms
Homologs of HSPA5 in Model Organisms
- Caenorhabditis elegans
- hsp-4
- Danio rerio
- hspa5
- Drosophila melanogaster
- Hsc70-3
- Mus musculus
- Hspa5
- Rattus norvegicus
- Hspa5
- Saccharomyces cerevisiae
- KAR2
- Schizosaccharomyces pombe
- bip1
In other databases
- GenAge model organism genes
- GenDR gene expression
- A homolog of this gene for Mus musculus is present as Hspa5
External links
- OMIM
- 138120
- Ensembl
- ENSG00000044574
- Entrez Gene
- 3309
- UniGene
- 743241
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- HSPA5
- GeneCards
- HSPA5