Cell Senescence Entries for HTRA1

Cell Types
Retinal pigment epithelial
Cell Lines
ARPE-19
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Induces
Primary Reference
Supanji et al. (2013) HtrA1 is induced by oxidative stress and enhances cell senescence through p38 MAPK pathway. Exp Eye Res 112(2)79-92 (PubMed)

HTRA1 Gene Information

HGNC symbol
HTRA1 
Aliases
ARMD7; HtrA; IGFBP5-protease; PRSS11 
Common name
HtrA serine peptidase 1 
Entrez Id
5654
Description
This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7. [provided by RefSeq, Jul 2008].

HTRA1 Ontologies

Gene Ontology
Process: GO:6508; proteolysis
GO:43065; positive regulation of apoptotic process
GO:12501; programmed cell death
GO:1890; placenta development
GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:30514; negative regulation of BMP signaling pathway
GO:50679; positive regulation of epithelial cell proliferation
GO:50687; negative regulation of defense response to virus
GO:60718; chorionic trophoblast cell differentiation
GO:97187; dentinogenesis
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5886; plasma membrane
GO:5576; extracellular region
GO:5829; cytosol
GO:70062; extracellular exosome
GO:62023; collagen-containing extracellular matrix
GO:5615; extracellular space
Function: GO:8233; peptidase activity
GO:16787; hydrolase activity
GO:4252; serine-type endopeptidase activity
GO:5515; protein binding
GO:19838; growth factor binding
GO:8236; serine-type peptidase activity
GO:42802; identical protein binding
Show all GO terms

Homologs of HTRA1 in Model Organisms

Danio rerio
htra1a
Drosophila melanogaster
HtrA2
Mus musculus
Htra1
Rattus norvegicus
Htra1

In other databases

CellAge gene expression
  • This gene is present as HTRA1

External links

OMIM
602194
Ensembl
ENSG00000166033
Entrez Gene
5654
UniGene
501280
1000 Genomes
1000 Genomes
HPRD
GenAtlas
HTRA1
GeneCards
HTRA1