Cell Senescence Entries for IFNG

Cell Types
Umbilical vein endothelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Kim et al. (2009) Interferon-gamma induces cellular senescence through p53-dependent DNA damage signaling in human endothelial cells. Mech Ageing Dev 130(3)179-88 (PubMed)

IFNG Gene Information

HGNC symbol
IFNG 
Aliases
 
Common name
interferon gamma 
Entrez Id
3458
Description
This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015].

IFNG Ontologies

Gene Ontology
Process: GO:50729; positive regulation of inflammatory response
GO:10629; negative regulation of gene expression
GO:7165; signal transduction
GO:51607; defense response to virus
GO:6955; immune response
GO:40008; regulation of growth
GO:10508; positive regulation of autophagy
GO:10628; positive regulation of gene expression
GO:8284; positive regulation of cell population proliferation
GO:32735; positive regulation of interleukin-12 production
GO:32834; positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response
And 63 more GO terms
Cellular component: GO:5576; extracellular region
GO:5615; extracellular space
Function: GO:5515; protein binding
GO:5125; cytokine activity
GO:5133; interferon-gamma receptor binding
Show all GO terms

Homologs of IFNG in Model Organisms

Danio rerio
ifng1-2
Mus musculus
Ifng
Rattus norvegicus
Ifng

In other databases

LongevityMap
  • This gene is present as IFNG

External links

OMIM
147570
Ensembl
ENSG00000111537
Entrez Gene
3458
UniGene
856
1000 Genomes
1000 Genomes
HPRD
GenAtlas
IFNG
GeneCards
IFNG