Cell Senescence Entries for IGFBP1

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Zuo et al. (2012) IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells. J Cancer Res Clin Oncol 138(6)1045-55 (PubMed)

IGFBP1 Gene Information

HGNC symbol
IGFBP1 
Aliases
AFBP; hIGFBP-1; IBP1; IGF-BP25; PP12 
Common name
insulin like growth factor binding protein 1 
Entrez Id
3484
Description
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients. [provided by RefSeq, Aug 2017].

IGFBP1 Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:7568; aging
GO:8286; insulin receptor signaling pathway
GO:30307; positive regulation of cell growth
GO:42246; tissue regeneration
GO:43567; regulation of insulin-like growth factor receptor signaling pathway
Cellular component: GO:5794; Golgi apparatus
GO:5576; extracellular region
GO:5615; extracellular space
GO:5788; endoplasmic reticulum lumen
Function: GO:5520; insulin-like growth factor binding
GO:19838; growth factor binding
GO:5515; protein binding
GO:31994; insulin-like growth factor I binding
GO:5102; signaling receptor binding
GO:31995; insulin-like growth factor II binding
Show all GO terms

Homologs of IGFBP1 in Model Organisms

Danio rerio
igfbp1b
Mus musculus
Igfbp1
Rattus norvegicus
Igfbp1

In other databases

LongevityMap
  • This gene is present as IGFBP1

External links

OMIM
146730
Ensembl
ENSG00000146678
Entrez Gene
3484
UniGene
642938
1000 Genomes
1000 Genomes
HPRD
GenAtlas
IGFBP1
GeneCards
IGFBP1