Cell Senescence Entries for IKBKG

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Ho et al. (2012) HTLV-1 tax-induced rapid senescence is driven by the transcriptional activity of NF-κB and depends on chronically activated IKKα and p65/RelA. J Virol 86(17)9474-83 (PubMed)

IKBKG Gene Information

HGNC symbol
IKBKG 
Aliases
FIP-3; FIP3; Fip3p; IKK-gamma; IKKAP1; IKKG; IP1; IP2; NEMO; ZC2HC9 
Common name
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma 
Entrez Id
8517
Description
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016].

IKBKG Ontologies

Gene Ontology
Process: GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45087; innate immune response
GO:6954; inflammatory response
GO:50852; T cell receptor signaling pathway
GO:43122; regulation of I-kappaB kinase/NF-kappaB signaling
GO:50862; positive regulation of T cell receptor signaling pathway
GO:9615; response to virus
GO:6955; immune response
GO:51092; positive regulation of NF-kappaB transcription factor activity
And 9 more GO terms
Cellular component: GO:5829; cytosol
GO:5634; nucleus
GO:5737; cytoplasm
GO:32991; protein-containing complex
GO:922; spindle pole
GO:5654; nucleoplasm
GO:72686; mitotic spindle
GO:8385; IkappaB kinase complex
GO:151; ubiquitin ligase complex
Function: GO:70530; K63-linked polyubiquitin modification-dependent protein binding
GO:5515; protein binding
GO:46872; metal ion binding
GO:42803; protein homodimerization activity
GO:42802; identical protein binding
GO:19904; protein domain specific binding
GO:46982; protein heterodimerization activity
GO:1990459; transferrin receptor binding
GO:31625; ubiquitin protein ligase binding
GO:1990450; linear polyubiquitin binding
GO:16301; kinase activity
And 1 more GO terms
Show all GO terms

Homologs of IKBKG in Model Organisms

Danio rerio
ikbkg
Mus musculus
Ikbkg
Rattus norvegicus
Ikbkg

External links

OMIM
300248
Ensembl
ENSG00000269335
Entrez Gene
8517
UniGene
43505
1000 Genomes
1000 Genomes
HPRD
GenAtlas
IKBKG
GeneCards
IKBKG