Cell Senescence Entries for ILK

Cell Types
Retinoblastoma
Cell Lines
Rb116
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Duminuco et al. (2016) Integrin-linked kinase regulates senescence in an Rb-dependent manner in cancer cell lines. Cell Cycle 14(18)2924-37 (PubMed)

ILK Gene Information

HGNC symbol
ILK 
Aliases
 
Common name
integrin linked kinase 
Entrez Id
3611
Description
This gene encodes a protein with a kinase-like domain and four ankyrin-like repeats. The encoded protein associates at the cell membrane with the cytoplasmic domain of beta integrins, where it regulates integrin-mediated signal transduction. Activity of this protein is important in the epithelial to mesenchymal transition, and over-expression of this gene is implicated in tumor growth and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013].

ILK Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:1934; positive regulation of protein phosphorylation
GO:45893; positive regulation of transcription, DNA-templated
GO:90263; positive regulation of canonical Wnt signaling pathway
GO:42327; positive regulation of phosphorylation
GO:34446; substrate adhesion-dependent cell spreading
GO:7160; cell-matrix adhesion
GO:7229; integrin-mediated signaling pathway
GO:70527; platelet aggregation
GO:1901224; positive regulation of NIK/NF-kappaB signaling
And 19 more GO terms
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:5925; focal adhesion
GO:30054; cell junction
GO:42995; cell projection
GO:30027; lamellipodium
GO:30017; sarcomere
GO:5829; cytosol
GO:1725; stress fiber
And 1 more GO terms
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:19901; protein kinase binding
Show all GO terms

Homologs of ILK in Model Organisms

Caenorhabditis elegans
pat-4
Danio rerio
ilk
Drosophila melanogaster
Ilk
Mus musculus
Ilk
Rattus norvegicus
Ilk

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as pat-4
  • A homolog of this gene for Drosophila melanogaster is present as Ilk

External links

OMIM
602366
Ensembl
ENSG00000166333
Entrez Gene
3611
UniGene
706355
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ILK
GeneCards
ILK