Cell Senescence Entries for INPP4B

Cell Types
Mammary epithelial
Cell Lines
HMEC
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Gewinner et al. (2009) Evidence that inositol polyphosphate 4-phosphatase type II is a tumor suppressor that inhibits PI3K signaling. Cancer Cell 16(2)115-25 (PubMed)

INPP4B Gene Information

HGNC symbol
INPP4B 
Aliases
 
Common name
inositol polyphosphate-4-phosphatase type II B 
Entrez Id
8821
Description
INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq, Jul 2008].

INPP4B Ontologies

Gene Ontology
Process: GO:6629; lipid metabolic process
GO:36092; phosphatidylinositol-3-phosphate biosynthetic process
GO:7165; signal transduction
GO:6661; phosphatidylinositol biosynthetic process
GO:43647; inositol phosphate metabolic process
GO:46855; inositol phosphate dephosphorylation
GO:46856; phosphatidylinositol dephosphorylation
GO:16311; dephosphorylation
Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
GO:16020; membrane
GO:16021; integral component of membrane
Function: GO:16787; hydrolase activity
GO:16316; phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
GO:34597; phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity
GO:5515; protein binding
GO:17161; inositol-1,3,4-trisphosphate 4-phosphatase activity
GO:52828; inositol-3,4-bisphosphate 4-phosphatase activity
Show all GO terms

Homologs of INPP4B in Model Organisms

Caenorhabditis elegans
CELE_R01H10.7
Danio rerio
inpp4b
Drosophila melanogaster
CG33249
Mus musculus
Inpp4b
Rattus norvegicus
Inpp4b

External links

OMIM
607494
Ensembl
ENSG00000109452
Entrez Gene
8821
UniGene
531403
1000 Genomes
1000 Genomes
HPRD
GenAtlas
INPP4B
GeneCards
INPP4B