Cell Senescence Entries for IRF1

Cell Types
Foreskin fibroblast, Melanocyte
Cell Lines
BJ, Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Wajapeyee et al. (2008) Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 132(3)363-74 (PubMed)

IRF1 Gene Information

HGNC symbol
IRF1 
Aliases
MAR 
Common name
interferon regulatory factor 1 
Entrez Id
3659
Description
The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017].

IRF1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6915; apoptotic process
GO:8285; negative regulation of cell population proliferation
GO:50776; regulation of immune response
GO:45892; negative regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:2376; immune system process
GO:45087; innate immune response
GO:51607; defense response to virus
GO:45088; regulation of innate immune response
And 16 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:785; chromatin
GO:5654; nucleoplasm
GO:5829; cytosol
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:976; transcription cis-regulatory region binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:43565; sequence-specific DNA binding
Show all GO terms

Homologs of IRF1 in Model Organisms

Danio rerio
irf1b
Mus musculus
Irf1
Rattus norvegicus
Irf1

External links

OMIM
147575
Ensembl
ENSG00000125347
Entrez Gene
3659
UniGene
436061
1000 Genomes
1000 Genomes
HPRD
GenAtlas
IRF1
GeneCards
IRF1