Cell Senescence Entries for IRF3

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Kim et al. (2006) Interferon regulatory factor 3 activates p53-dependent cell growth inhibition. Cancer Lett 242(2)215-21 (PubMed)

IRF3 Gene Information

HGNC symbol
IRF3 
Aliases
 
Common name
interferon regulatory factor 3 
Entrez Id
3661
Description
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7. [provided by RefSeq, Sep 2020].

IRF3 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:60333; interferon-gamma-mediated signaling pathway
GO:6915; apoptotic process
GO:6974; cellular response to DNA damage stimulus
GO:2376; immune system process
GO:45087; innate immune response
GO:51607; defense response to virus
GO:122; negative regulation of transcription by RNA polymerase II
GO:6357; regulation of transcription by RNA polymerase II
GO:42981; regulation of apoptotic process
GO:98586; cellular response to virus
And 22 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:5829; cytosol
GO:5739; mitochondrion
GO:785; chromatin
GO:5654; nucleoplasm
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:976; transcription cis-regulatory region binding
GO:5515; protein binding
GO:42803; protein homodimerization activity
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:43565; sequence-specific DNA binding
And 4 more GO terms
Show all GO terms

Homologs of IRF3 in Model Organisms

Mus musculus
Irf3
Rattus norvegicus
Irf3

External links

OMIM
603734
Ensembl
ENSG00000126456
Entrez Gene
3661
UniGene
289052
1000 Genomes
1000 Genomes
HPRD
GenAtlas
IRF3
GeneCards
IRF3