Cell Senescence Entries for ITGB3

Cell Types
Breast cancer, Liver cancer, Lung fibroblast
Cell Lines
IMR-90, MCF-7, SK-HEP-1
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced, Stress-induced
Senescence Effect
Induces
Primary Reference
Rapisarda et al. (2017) Integrin Beta 3 Regulates Cellular Senescence by Activating the TGF-β Pathway. Cell Rep 18(10)2480-2493 (PubMed)

ITGB3 Gene Information

HGNC symbol
ITGB3 
Aliases
CD61; GP3A; GPIIIa 
Common name
integrin subunit beta 3 
Entrez Id
3690
Description
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008].

ITGB3 Ontologies

Gene Ontology
Process: GO:7155; cell adhesion
GO:30168; platelet activation
GO:7229; integrin-mediated signaling pathway
GO:16477; cell migration
GO:32880; regulation of protein localization
GO:7160; cell-matrix adhesion
GO:33627; cell adhesion mediated by integrin
GO:70527; platelet aggregation
GO:50731; positive regulation of peptidyl-tyrosine phosphorylation
GO:1938; positive regulation of endothelial cell proliferation
GO:7596; blood coagulation
And 26 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:5925; focal adhesion
GO:30054; cell junction
GO:42995; cell projection
GO:45202; synapse
GO:42470; melanosome
GO:9986; cell surface
GO:45211; postsynaptic membrane
And 19 more GO terms
Function: GO:5515; protein binding
GO:3756; protein disulfide isomerase activity
GO:19899; enzyme binding
GO:42802; identical protein binding
GO:5178; integrin binding
GO:1968; fibronectin binding
GO:50840; extracellular matrix binding
GO:2020; protease binding
GO:1618; virus receptor activity
GO:43184; vascular endothelial growth factor receptor 2 binding
GO:15026; coreceptor activity
And 7 more GO terms
Show all GO terms

Homologs of ITGB3 in Model Organisms

Caenorhabditis elegans
pat-3
Danio rerio
itgb3b
Drosophila melanogaster
mys
Mus musculus
Itgb3
Rattus norvegicus
Itgb3

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as mys
  • A homolog of this gene for Caenorhabditis elegans is present as pat-3
LongevityMap
  • This gene is present as ITGB3

External links

OMIM
173470
Ensembl
ENSG00000259207
Entrez Gene
3690
UniGene
218040
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ITGB3
GeneCards
ITGB3