Cell Senescence Entries for ITPKB

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

ITPKB Gene Information

HGNC symbol
ITPKB 
Aliases
IP3-3KB; IP3KB 
Common name
inositol-trisphosphate 3-kinase B 
Entrez Id
3707
Description
The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008].

ITPKB Ontologies

Gene Ontology
Process: GO:16310; phosphorylation
GO:32958; inositol phosphate biosynthetic process
GO:46854; phosphatidylinositol phosphate biosynthetic process
GO:7165; signal transduction
GO:71277; cellular response to calcium ion
GO:32957; inositol trisphosphate metabolic process
GO:165; MAPK cascade
GO:1932; regulation of protein phosphorylation
GO:2262; myeloid cell homeostasis
GO:7166; cell surface receptor signaling pathway
GO:30217; T cell differentiation
And 8 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:16020; membrane
Function: GO:166; nucleotide binding
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:5515; protein binding
GO:5516; calmodulin binding
GO:828; inositol hexakisphosphate kinase activity
GO:8440; inositol-1,4,5-trisphosphate 3-kinase activity
Show all GO terms

Homologs of ITPKB in Model Organisms

Danio rerio
itpkb
Mus musculus
Itpkb
Rattus norvegicus
Itpkb

External links

OMIM
147522
Ensembl
ENSG00000143772
Entrez Gene
3707
UniGene
659396
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ITPKB
GeneCards
ITPKB