Cell Senescence Entries for JUN

Cell Types
Breast cancer
Cell Lines
MCF-7
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Duan et al. (2007) Inducible overexpression of c-Jun in MCF7 cells causes resistance to vinblastine via inhibition of drug-induced apoptosis and senescence at a step subsequent to mitotic arrest. Biochem Pharmacol 73(4)481-90 (PubMed)

JUN Gene Information

HGNC symbol
JUN 
Aliases
AP-1; c-Jun 
Common name
Jun proto-oncogene, AP-1 transcription factor subunit 
Entrez Id
3725
Description
This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008].

JUN Ontologies

Gene Ontology
Process: GO:1904707; positive regulation of vascular associated smooth muscle cell proliferation
GO:6355; regulation of transcription, DNA-templated
GO:45892; negative regulation of transcription, DNA-templated
GO:50790; regulation of catalytic activity
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:7265; Ras protein signal transduction
GO:122; negative regulation of transcription by RNA polymerase II
GO:51726; regulation of cell cycle
GO:42127; regulation of cell population proliferation
And 34 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:785; chromatin
GO:5667; transcription regulator complex
GO:90575; RNA polymerase II transcription regulator complex
GO:35976; transcription factor AP-1 complex
GO:228; nuclear chromosome
GO:791; euchromatin
GO:17053; transcription repressor complex
Function: GO:3723; RNA binding
GO:3677; DNA binding
GO:31625; ubiquitin protein ligase binding
GO:3700; DNA-binding transcription factor activity
GO:5096; GTPase activator activity
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:19899; enzyme binding
GO:42802; identical protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
And 10 more GO terms
Show all GO terms

Homologs of JUN in Model Organisms

Danio rerio
jun
Mus musculus
Jun
Rattus norvegicus
Jun

In other databases

GenAge human genes
  • This gene is present as JUN

External links

OMIM
165160
Ensembl
ENSG00000177606
Entrez Gene
3725
UniGene
696684
1000 Genomes
1000 Genomes
HPRD
GenAtlas
JUN
GeneCards
JUN