Cell Senescence Entries for KAT5

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Zheng et al. (2013) A posttranslational modification cascade involving p38, Tip60, and PRAK mediates oncogene-induced senescence. Mol Cell 50(5)699-710 (PubMed)

KAT5 Gene Information

HGNC symbol
KAT5 
Aliases
cPLA2; ESA1; HTATIP; HTATIP1; PLIP; TIP60; ZC2HC5 
Common name
lysine acetyltransferase 5 
Entrez Id
10524
Description
The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].

KAT5 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:40008; regulation of growth
GO:6302; double-strand break repair
GO:16573; histone acetylation
GO:6289; nucleotide-excision repair
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1902036; regulation of hematopoietic stem cell differentiation
And 32 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5730; nucleolus
GO:123; histone acetyltransferase complex
GO:48471; perinuclear region of cytoplasm
GO:35267; NuA4 histone acetyltransferase complex
GO:776; kinetochore
GO:97431; mitotic spindle pole
And 5 more GO terms
Function: GO:46872; metal ion binding
GO:16740; transferase activity
GO:16746; acyltransferase activity
GO:5515; protein binding
GO:4402; histone acetyltransferase activity
GO:3713; transcription coactivator activity
GO:42393; histone binding
GO:3682; chromatin binding
GO:3712; transcription coregulator activity
GO:140297; DNA-binding transcription factor binding
GO:16407; acetyltransferase activity
And 7 more GO terms
Show all GO terms

Homologs of KAT5 in Model Organisms

Caenorhabditis elegans
mys-1
Danio rerio
zgc:92510
Drosophila melanogaster
Tip60
Mus musculus
Kat5
Rattus norvegicus
Kat5
Saccharomyces cerevisiae
ESA1
Schizosaccharomyces pombe
mst1

External links

OMIM
601409
Ensembl
ENSG00000172977
Entrez Gene
10524
UniGene
397010
1000 Genomes
1000 Genomes
HPRD
GenAtlas
KAT5
GeneCards
KAT5