Cell Senescence Entries for KCNJ12

Cell Types
Breast cancer, Gastric cancer, Prostate cancer
Cell Lines
DU145, LNCaP, MCF-7, MKN74, PC-3, SK-BR-3, SNU-484, SNU-638, SNU-668, T47D
Cancer Cell?
Yes
Method
Knockout
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Lee et al. (2011) Knockdown of inwardly rectifying potassium channel Kir2.2 suppresses tumorigenesis by inducing reactive oxygen species-mediated cellular senescence. Mol Cancer Ther 9(11)2951-9 (PubMed)

KCNJ12 Gene Information

HGNC symbol
KCNJ12 
Aliases
hIRK1; IRK2; KCNJN1; Kir2.2; Kir2.2v 
Common name
potassium inwardly rectifying channel subfamily J member 12 
Entrez Id
3768
Description
This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008].

KCNJ12 Ontologies

Gene Ontology
Process: GO:6811; ion transport
GO:6813; potassium ion transport
GO:34765; regulation of ion transmembrane transport
GO:1990573; potassium ion import across plasma membrane
GO:6936; muscle contraction
GO:51289; protein homotetramerization
GO:8016; regulation of heart contraction
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:31224; intrinsic component of membrane
Function: GO:5244; voltage-gated ion channel activity
GO:5515; protein binding
GO:5242; inward rectifier potassium channel activity
Show all GO terms

Homologs of KCNJ12 in Model Organisms

No homologs found

External links

OMIM
602323
Ensembl
ENSG00000184185
Entrez Gene
3768
UniGene
200629
1000 Genomes
1000 Genomes
HPRD
GenAtlas
KCNJ12
GeneCards
KCNJ12