Cell Senescence Entries for KDM6B

Cell Types
Glioblastoma
Cell Lines
U251, U87
Cancer Cell?
Yes
Method
Knockdown, Mutation
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Perrigue et al. (2016) The histone demethylase jumonji coordinates cellular senescence including secretion of neural stem cell-attracting cytokines. Mol Cancer Res 13(4)636-50 (PubMed)

KDM6B Gene Information

HGNC symbol
KDM6B 
Aliases
JMJD3; KIAA0346 
Common name
lysine demethylase 6B 
Entrez Id
23135
Description
The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me2 or H3K27me3). H3K27 trimethylation is a repressive epigenetic mark controlling chromatin organization and gene silencing. This protein can also demethylate non-histone proteins such as retinoblastoma protein. Through its demethylation actvity this gene influences cellular differentiation and development, tumorigenesis, inflammatory diseases, and neurodegenerative diseases. This protein has two classical nuclear localization signals at its N-terminus. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2017].

KDM6B Ontologies

Gene Ontology
Process: GO:6325; chromatin organization
GO:6954; inflammatory response
GO:6338; chromatin remodeling
GO:10468; regulation of gene expression
GO:71557; histone H3-K27 demethylation
GO:7507; heart development
GO:45944; positive regulation of transcription by RNA polymerase II
GO:120162; positive regulation of cold-induced thermogenesis
GO:16577; histone demethylation
GO:45165; cell fate commitment
GO:45446; endothelial cell differentiation
And 4 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:44666; MLL3/4 complex
Function: GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:51213; dioxygenase activity
GO:5515; protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:31490; chromatin DNA binding
GO:71558; histone demethylase activity (H3-K27 specific)
GO:32452; histone demethylase activity
GO:8013; beta-catenin binding
GO:43565; sequence-specific DNA binding
Show all GO terms

Homologs of KDM6B in Model Organisms

Caenorhabditis elegans
utx-1
Danio rerio
kdm6bb
Mus musculus
Kdm6b
Rattus norvegicus
Kdm6b
Saccharomyces cerevisiae
CYC8

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as utx-1

External links

OMIM
611577
Ensembl
ENSG00000132510
Entrez Gene
23135
UniGene
223678
1000 Genomes
1000 Genomes
HPRD
GenAtlas
KDM6B
GeneCards
KDM6B