Cell Senescence Entries for KDR

Cell Types
Glioblastoma
Cell Lines
U-373MG
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Jones et al. (2017) Selective coexpression of VEGF receptor 2 in EGFRvIII-positive glioblastoma cells prevents cellular senescence and contributes to their aggressive nature. Neuro Oncol 18(5)667-78 (PubMed)

KDR Gene Information

HGNC symbol
KDR 
Aliases
CD309; FLK1; VEGFR; VEGFR2 
Common name
kinase insert domain receptor 
Entrez Id
3791
Description
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009].

KDR Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:43066; negative regulation of apoptotic process
GO:7169; transmembrane receptor protein tyrosine kinase signaling pathway
GO:30154; cell differentiation
GO:1934; positive regulation of protein phosphorylation
GO:1525; angiogenesis
GO:8284; positive regulation of cell population proliferation
GO:46777; protein autophosphorylation
GO:48010; vascular endothelial growth factor receptor signaling pathway
GO:45766; positive regulation of angiogenesis
And 56 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5794; Golgi apparatus
GO:31410; cytoplasmic vesicle
GO:5783; endoplasmic reticulum
GO:5886; plasma membrane
GO:5768; endosome
GO:5576; extracellular region
GO:30054; cell junction
And 9 more GO terms
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4713; protein tyrosine kinase activity
GO:4714; transmembrane receptor protein tyrosine kinase activity
GO:5515; protein binding
GO:42802; identical protein binding
GO:5021; vascular endothelial growth factor-activated receptor activity
And 6 more GO terms
Show all GO terms

Homologs of KDR in Model Organisms

Danio rerio
kdr
Mus musculus
Kdr
Rattus norvegicus
Kdr

External links

OMIM
191306
Ensembl
ENSG00000128052
Entrez Gene
3791
UniGene
479756
1000 Genomes
1000 Genomes
HPRD
GenAtlas
KDR
GeneCards
KDR