Cell Senescence Entries for KIF2C

Cell Types
Dermal fibroblast, Umbilical vein endothelial
Cell Lines
HUVEC, Primary cell
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Gwon et al. (2013) Mitotic centromere-associated kinase (MCAK/Kif2C) regulates cellular senescence in human primary cells through a p53-dependent pathway. FEBS Lett 586(23)4148-56 (PubMed)

KIF2C Gene Information

HGNC symbol
KIF2C 
Aliases
CT139; KNSL6; MCAK 
Common name
kinesin family member 2C 
Entrez Id
11004
Description
This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

KIF2C Ontologies

Gene Ontology
Process: GO:7018; microtubule-based movement
GO:7049; cell cycle
GO:51301; cell division
GO:7059; chromosome segregation
GO:7019; microtubule depolymerization
GO:51310; metaphase plate congression
GO:51315; attachment of mitotic spindle microtubules to kinetochore
GO:7080; mitotic metaphase plate congression
GO:51983; regulation of chromosome segregation
GO:30951; establishment or maintenance of microtubule cytoskeleton polarity
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5856; cytoskeleton
GO:5694; chromosome
GO:5874; microtubule
GO:775; chromosome, centromeric region
GO:776; kinetochore
GO:5813; centrosome
GO:5819; spindle
GO:5829; cytosol
And 5 more GO terms
Function: GO:166; nucleotide binding
GO:5524; ATP binding
GO:3774; cytoskeletal motor activity
GO:8017; microtubule binding
GO:3777; microtubule motor activity
GO:5515; protein binding
GO:16887; ATP hydrolysis activity
GO:19237; centromeric DNA binding
GO:51010; microtubule plus-end binding
Show all GO terms

Homologs of KIF2C in Model Organisms

Drosophila melanogaster
Klp10A
Mus musculus
Kif2c
Rattus norvegicus
Kif2c

In other databases

CellAge gene expression
  • This gene is present as KIF2C

External links

OMIM
604538
Ensembl
ENSG00000142945
Entrez Gene
11004
UniGene
720061
1000 Genomes
1000 Genomes
HPRD
GenAtlas
KIF2C
GeneCards
KIF2C