Cell Senescence Entries for KL

Cell Types
Lung fibroblast
Cell Lines
MRC-5, WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
de Oliveira et al. (2006) Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway. FEBS Lett 580(24)5753-8 (PubMed)

KL Gene Information

HGNC symbol
KL 
Aliases
KLA 
Common name
klotho 
Entrez Id
9365
Description
This gene encodes a type-I membrane protein that is related to beta-glucosidases. Reduced production of this protein has been observed in patients with chronic renal failure (CRF), and this may be one of the factors underlying the degenerative processes (e.g., arteriosclerosis, osteoporosis, and skin atrophy) seen in CRF. Also, mutations within this protein have been associated with ageing and bone loss. [provided by RefSeq, Jul 2008].

KL Ontologies

Gene Ontology
Process: GO:5975; carbohydrate metabolic process
GO:8152; metabolic process
GO:8543; fibroblast growth factor receptor signaling pathway
GO:7568; aging
GO:30501; positive regulation of bone mineralization
GO:8286; insulin receptor signaling pathway
GO:2526; acute inflammatory response
GO:3085; negative regulation of systemic arterial blood pressure
GO:6112; energy reserve metabolic process
GO:14823; response to activity
GO:33280; response to vitamin D
GO:42421; norepinephrine biosynthetic process
GO:55074; calcium ion homeostasis
GO:71774; response to fibroblast growth factor
GO:90080; positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:1990776; response to angiotensin
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5615; extracellular space
GO:5886; plasma membrane
GO:5576; extracellular region
GO:16324; apical plasma membrane
GO:70062; extracellular exosome
GO:5887; integral component of plasma membrane
Function: GO:16787; hydrolase activity
GO:4553; hydrolase activity, hydrolyzing O-glycosyl compounds
GO:16798; hydrolase activity, acting on glycosyl bonds
GO:5179; hormone activity
GO:5499; vitamin D binding
GO:5104; fibroblast growth factor receptor binding
GO:17134; fibroblast growth factor binding
GO:4566; beta-glucuronidase activity
GO:8422; beta-glucosidase activity
Hide GO terms

Homologs of KL in Model Organisms

Danio rerio
kl
Mus musculus
Kl
Rattus norvegicus
Kl

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Kl
GenAge human genes
  • This gene is present as KL
LongevityMap
  • This gene is present as KL

External links

OMIM
604824
Ensembl
ENSG00000133116
Entrez Gene
9365
UniGene
524953
1000 Genomes
1000 Genomes
HPRD
GenAtlas
KL
GeneCards
KL