Cell Senescence Entries for KNDC1

Cell Types
Umbilical vein endothelial
Cell Lines
HUVEC
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ji et al. (2018) Effect of KNDC1 overexpression on the senescence of human umbilical vein endothelial cells. Mol Med Rep 17(5)7037-7044 (PubMed)

KNDC1 Gene Information

HGNC symbol
KNDC1 
Aliases
bB439H18.3; C10orf23; FLJ25027; KIAA1768; RASGEF2; v-KIND; Very-KIND 
Common name
kinase non-catalytic C-lobe domain containing 1 
Entrez Id
85442
Description
The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies. [provided by RefSeq, Dec 2016].

KNDC1 Ontologies

Gene Ontology
Process: GO:7264; small GTPase mediated signal transduction
GO:50790; regulation of catalytic activity
GO:1934; positive regulation of protein phosphorylation
GO:8150; biological_process
GO:48814; regulation of dendrite morphogenesis
GO:50773; regulation of dendrite development
GO:21707; cerebellar granule cell differentiation
Cellular component: GO:42995; cell projection
GO:30425; dendrite
GO:43204; perikaryon
GO:5575; cellular_component
GO:43025; neuronal cell body
GO:32045; guanyl-nucleotide exchange factor complex
Function: GO:5085; guanyl-nucleotide exchange factor activity
GO:3674; molecular_function
Show all GO terms

Homologs of KNDC1 in Model Organisms

Mus musculus
Kndc1
Rattus norvegicus
Kndc1

External links

OMIM
616237
Ensembl
ENSG00000171798
Entrez Gene
85442
UniGene
530685
1000 Genomes
1000 Genomes
HPRD
GenAtlas
KNDC1
GeneCards
KNDC1