Cell Senescence Entries for KRT19

Cell Types
Liver cancer
Cell Lines
PLC/PRF/5
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Takano et al. (2017) Keratin 19 as a key molecule in progression of human hepatocellular carcinomas through invasion and angiogenesis. BMC Cancer 16(1)903 (PubMed)

KRT19 Gene Information

HGNC symbol
KRT19 
Aliases
CK19; K19; K1CS; MGC15366 
Common name
keratin 19 
Entrez Id
3880
Description
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008].

KRT19 Ontologies

Gene Ontology
Process: GO:30855; epithelial cell differentiation
GO:45109; intermediate filament organization
GO:43627; response to estrogen
GO:7219; Notch signaling pathway
GO:45214; sarcomere organization
GO:60706; cell differentiation involved in embryonic placenta development
Cellular component: GO:5882; intermediate filament
GO:5856; cytoskeleton
GO:5829; cytosol
GO:70062; extracellular exosome
GO:5886; plasma membrane
GO:43034; costamere
GO:71944; cell periphery
GO:16327; apicolateral plasma membrane
GO:30018; Z disc
GO:42383; sarcolemma
GO:1990357; terminal web
And 1 more GO terms
Function: GO:5198; structural molecule activity
GO:5515; protein binding
GO:5200; structural constituent of cytoskeleton
GO:8307; structural constituent of muscle
Show all GO terms

Homologs of KRT19 in Model Organisms

Mus musculus
Krt19
Rattus norvegicus
Krt19

External links

OMIM
148020
Ensembl
ENSG00000171345
Entrez Gene
3880
UniGene
654568
1000 Genomes
1000 Genomes
HPRD
GenAtlas
KRT19
GeneCards
KRT19