Cell Senescence Entries for LAMP2

Cell Types
Foreskin fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Kang et al. (2012) Autophagy impairment induces premature senescence in primary human fibroblasts. PLoS One 6(8)e23367 (PubMed)

LAMP2 Gene Information

HGNC symbol
LAMP2 
Aliases
CD107b 
Common name
lysosomal associated membrane protein 2 
Entrez Id
3920
Description
The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2008].

LAMP2 Ontologies

Gene Ontology
Process: GO:6914; autophagy
GO:97352; autophagosome maturation
GO:9267; cellular response to starvation
GO:6605; protein targeting
GO:31647; regulation of protein stability
GO:31333; negative regulation of protein-containing complex assembly
GO:50821; protein stabilization
GO:61684; chaperone-mediated autophagy
GO:61740; protein targeting to lysosome involved in chaperone-mediated autophagy
GO:72594; establishment of protein localization to organelle
GO:17038; protein import
And 3 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:31410; cytoplasmic vesicle
GO:43231; intracellular membrane-bounded organelle
GO:5886; plasma membrane
GO:5768; endosome
GO:5765; lysosomal membrane
GO:5615; extracellular space
GO:10008; endosome membrane
GO:5764; lysosome
GO:421; autophagosome membrane
And 15 more GO terms
Function: GO:19899; enzyme binding
GO:5515; protein binding
GO:19904; protein domain specific binding
Show all GO terms

Homologs of LAMP2 in Model Organisms

Drosophila melanogaster
Lamp1
Mus musculus
Lamp2
Rattus norvegicus
Lamp2

External links

OMIM
309060
Ensembl
ENSG00000005893
Entrez Gene
3920
UniGene
496684
1000 Genomes
1000 Genomes
HPRD
GenAtlas
LAMP2
GeneCards
LAMP2